Research and Development Chemical Engineer

Core Block  High Point, North Carolina, United States (On-site)

Position: Research & Development Chemical Engineer

Location: High Point, North Carolina

Department: Process Chemistry

Type: Full Time

Compensation: DOE

Job Description

Summary

Seeking a dedicated, reliable, and experienced Research & Development Chemical Engineer for the role which is directed toward optimization of existing chemical routes and development of novel alternate chemistries/processes toward key synthetic intermediates and APIs.

The ideal candidate will provide CHP site engineering support, including the design, construction, and maintenance of equipment that replicates laboratory chemical processes on pilot and commercial scales. Experimental skills related to chemical process development and kilo-scale synthesis of organic compounds of medicinal importance, including chemical synthesis and product isolation/purification is a desired. Utilizes analytical tools to assess product quality and process performance. Serves as an expert chemical engineering and pharmaceutical science resource to the chemical development group, at the High Point site, and to the larger organization.

Communicated with clients in regular team meetings; prepares R&D and campaign reports at the conclusion of projects.

Responsibilities:

• Design and carry out multistep organic processes.
• Application of key principles of chemical engineering to work within a matrix-based chemical development team to construct systems and design chemical processes that will efficiently support the on-scale safe production of promising pharmaceutical candidates.
• Knowledge and experience in technologies such as continuous processing and flow chemistry are preferred.
• Knowledge and experience with cGMP manufacturing processes are preferred.
• Knowledge of and experience with in-situ reaction monitoring technology is preferred.
• Knowledge of final form screening/polymorph screening/crystallization studies is preferred.
• Knowledge of process controls and associated programming is preferred.
• Possess a working knowledge of analytical and spectroscopic techniques, including the ability to interpret the corresponding data.
• Demonstrate proficiency in laboratory and pilot-scale synthesis and purification techniques, including the implementation of process modifications.
• Demonstrate an ability to maintain lab equipment including pumps and instrumentation.
• Ability to work with minimal supervision and complete projects independently.
• Ability to organize work efficiently and manage time effectively.
• Ability to write comprehensive reports and contribute to the drafting of batch records and protocols.
• Collaboration with process development chemists and analytical chemists to coordinate project activities as well as to develop safer and more robust processes for laboratory and plant production.
• Maintain current knowledge of state-of-the-art techniques for improving engineering principles related to organic chemistry, analytical chemistry, process development techniques, and cGMP regulations. Knowledge of root cause/batch failure analysis.
• Conduct laboratory operations in a safe manner. Maintain familiarity with the company’s chemical hygiene plan. Exhibit safety awareness and safe work practices.
• Follow responsible actions regarding chemical disposal. Maintain compliance with all regulations at the federal, state, and local levels.
• Address routine administrative requirements in a timely fashion.
• Demonstrate effective communication skills.
• Actively promote the results of ongoing projects within the group and to external clients.
• Work closely with manufacturing and GMP operations to coordinate project-related equipment and activities.
• Maintain a clean and safe lab work area.

Desirable Experience/Skills

• Strong skills and knowledge in organic chemistry, especially as applicable to process chemistry and chemical engineering principles. Excellent verbal and written communication/interpersonal skills, problem-solving skills, organizational skills, and the ability to work in a diverse team environment are essential. Proficiency with Microsoft software (Word / EXCEL / PowerPoint) is expected. Experience with engineering software and process modeling.
• Ph.D. in Chemical Engineering or Equivalent Degree
• MS. in Chemical Engineering or Equivalent Degree
• BS. in Chemical Engineering with 2-5 years of hands-on experience in the pharmaceutical or comparable chemical industry.

Core Block is an Equal Opportunity / Affirmative Action employer and will consider all qualified applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.